KiKi Shepard has died at 74, her family confirmed.

Shepard passed away after suffering from a heart attack on Monday, a representative said.

“It is with profound sadness that we announce the unexpected passing of our beloved KiKi Shepard, cherished Sister, Auntie, friend, and an unwavering advocate for those living with sickle cell disease,” Shepard’s family said in an emotional statement: “We thank everyone for the outpouring of love, prayers, and support during this incredibly difficult time.”

Shepard appeared on TV shows like “A Different World” and “Baywatch” and worked on Broadway in the 1970s and 80s.

She was also the longtime co-host of variety showcase “Showtime at the Apollo.”

The show filmed at Harlem’s famous Apollo Theater, giving both professional stars and up-and-coming artists a platform to perform.

Shepard was joined by several other celebrity co-hosts from 1987 to 2002, including Steve Harvey, Sinbad, and Mo’Nique.

“For 15 years, KiKi brought grace, warmth, and joy into the homes of millions as the beloved Co-Host of Showtime at the Apollo. She was also renowned as the Apollo Queen of Fashion and Ambassador of the show,” Shepard’s family said.

Shepard also founded The KIS Foundation, Inc., working to raise awareness, provide support and advocate for families affected by sickle cell disease.

“KiKi believed that compassion, community, and education could change lives. Her voice uplifted countless individuals who often felt unseen, and her work created lasting pathways for hope, resources, and understanding for those living with this disease,” her family highlighted her passion for service.

“The KIS Foundation will carry forward KiKi’s legacy of advocacy, empowerment, and care for the sickle cell community … She was our guiding light: strong, loving, joyful, and endlessly generous. To the community she served, she was a tireless champion and a source of inspiration.”

The Shepard family plans to share memorial service details in the coming days.

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